So I just got back. We stayed in the Pearl District at a local friend's recommendation and would highly recommend for short walking distance to great restaurants and sites. There are so many good microbrewery restaurants within the five block radius.
We stayed in what is possibly the nicest Hampton Inn I have ever seen on 9th and Everett.
If you are looking for a more fun, upscale boutique the Hoxton is not too far. I would stay at the one and only original in East London years ago for work and they have maintained the cool vibe during US expansion. We met some folks for a drink at the rooftop bar which has a great view of the skyline and Mt. Hood.
We valeted our car, so we did not have to worry about petty crime. I will say that is several days of walking it felt like on of the safer downtown areas I have been to. For a very progressive Pacific Northwest community, they seemed to have forced out the homeless in a big way.
Located here. You will see pretty much every brand name is nearby.
https://maps.app.goo.gl/oHaS7mUSsLzzXzML8