The new South Park special "The End of Obesity" has the kids navigating the American health care system to get Cartman semaglutide meds. Spot on.
GLP-1 Peptides Mounjaro/Tirzepatide, Ozempic/Wegovy/Semaglutide - any experience?
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Last: 2 mo ago by dmart90
Just reiterating. Please make sure you are maintaining a consistent workout program while taking these meds. These things take a decent chunk of lean body mass for the weight loss as well so you want to be training to help maintain your strength.
100%wangus12 said:
Just reiterating. Please make sure you are maintaining a consistent workout program while taking these meds. These things take a decent chunk of lean body mass for the weight loss as well so you want to be training to help maintain your strength.
You should also do consistent resistance training when dieting even if you're not using a GLP1.
Preferably, your resistance training should have more of a hypertrophy focus in order to preserve muscle
True Anomaly said:100%wangus12 said:
Just reiterating. Please make sure you are maintaining a consistent workout program while taking these meds. These things take a decent chunk of lean body mass for the weight loss as well so you want to be training to help maintain your strength.
You should also do consistent resistance training when dieting even if you're not using a GLP1.
Preferably, your resistance training should have more of a hypertrophy focus in order to preserve muscle
How much daily protein should we target? 1g per lb is what I've seen but there's no way I'm hitting that target. I assume it's lower if you have a BMI over 30. More of 1g per lb lean body mass might make more sense?
Anywhere from 0.7-1.2 g/pound of lean body weight is the optimal goal for body recomposition, based on the consensus of evidenceTeddy Perkins said:True Anomaly said:100%wangus12 said:
Just reiterating. Please make sure you are maintaining a consistent workout program while taking these meds. These things take a decent chunk of lean body mass for the weight loss as well so you want to be training to help maintain your strength.
You should also do consistent resistance training when dieting even if you're not using a GLP1.
Preferably, your resistance training should have more of a hypertrophy focus in order to preserve muscle
How much daily protein should we target? 1g per lb is what I've seen but there's no way I'm hitting that target. I assume it's lower if you have a BMI over 30. More of 1g per lb lean body mass might make more sense?
In my view, it's based upon your body fat percentage. The higher your body fat percentage is, then the harder it is to calculate your protein goals- so you just need to make an adjustment
- If you're actually 15% BF or less, then you can just use your actual body weight for the protein goal
- If you're 20% BF or above, then using "ideal body weight" for your protein goal is probably better just because it's easier to fit in and still see results
I truly believe ALL adults would benefit from consistently eating > 100 grams/protein per day
But none of this is truly optimized unless you do consistent resistance training, biased towards hypertrophy
I agree with the resistance stuff. I've been off GLP1 since my insurance stopped covering it nearly 2 years ago. Drifted up some but stablized and now dropping a bit with the only change is adding Tonal in 11/2023. Game changing machine for me, first time I've enjoyed lifting since high school and I'm actually seeing strength gains!No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Went to the doc today. A1C is down 2 points and I've lost about 12 pounds.
Starting Zepbound next week. Interested to see how it goes.
Eat 1/2 portions, high protein, high fiber, take a multivitamin. Slow down your eating pace significantly or you will overeat and feel horribly bloated.AggieMainland said:
Starting Zepbound next week. Interested to see how it goes.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
I started a thread for this video but thought this part would be relevant to this thread. Video is queued up at the part discussing Ozempic. Fair warning they are not fans.
I have crossfit trained for 1 year and have eaten healthy prepped meals consistently for the last year. I'm 5'10", 47 years old and started at 215 pounds. I was definitely stronger from working out but could only lose about 7 pounds, had flab everywhere, had crazy sugar urges and always thought about food. I had a BMI of 33%. I have been on a compounded semaglutide for about 4 months. I still workout 4-5 days/week. I still eat prepped meals but I now weigh 179 pounds. My BMI is about 23%. The semaglutide is the only thing I have changed. I went to my yearly checkup 2 weeks and all of my blood tests came back perfect! No pre-diabetes or anything even close to address. My doc emailed me to say that I was in exceptional shape and to keep up the semaglutide, eating properly and working out. My goal is 170-175. Eat properly, take fiber and drink a ton of water.
Any recs on where to get a semiglutide? One doctor gave a crazy high quote. Any luck with online places like Hims or Henrys?
Eli Lilly Issues Cease-And-Desist Letters to Compounders Over Weight-Loss Drug Copies As Shortage Resolves (yahoo.com)
Finding cheap tirzepatide GLP-1 from online compounding pharmacies may get more difficult with this action by Lilly.
Finding cheap tirzepatide GLP-1 from online compounding pharmacies may get more difficult with this action by Lilly.
I recommend Mochi. (referral code 4RBO4O for $40 off first virtual visit with doctor). Easy scheduling. Never had an issue with delivery. I picked them because they partner with the most well-known compounding pharmacies. Not the smaller ones no one has heard of).
$79/month for subscription + $99 for the semaglutide. So $178 per month total.
Required to meet with doctor every 3 months. They also have dietitians available. That is optional but included in the subscription. The doctor i work with on there lost a ton of weight on glp-1s so there is value there.
edit: the doctors name is Jeffrey Hackworth. Recommend if you go with Mochi.
$79/month for subscription + $99 for the semaglutide. So $178 per month total.
Required to meet with doctor every 3 months. They also have dietitians available. That is optional but included in the subscription. The doctor i work with on there lost a ton of weight on glp-1s so there is value there.
edit: the doctors name is Jeffrey Hackworth. Recommend if you go with Mochi.
My GP referred me to a local compounding pharmacy. I pay $148, delivered, for a 6 week supply of generic GLP-1 Semaglutide.VP at Pierce and Pierce said:
Any recs on where to get a semiglutide? One doctor gave a crazy high quote. Any luck with online places like Hims or Henrys?
I've been on it for about 4 months and have been on the 50 unit dosage for the about 3 months of that.
As of Friday I was down around 35 lbs. I can wear clothes I haven't been able to in years and am at a lower weight than when I got married 7.5 years ago.
It took awhile to get used to but now I just know that I can't eat as much. Plenty of leftovers.
Looking forward to losing another 20-30 lbs.
Same situation here. My idea is that I eat healthy and workout but couldn't lose weight. Just turned 50. started Tirzeptide 6 weeks ago and down about 16 pounds. Avg of 2-2.5 lbs per week. I took one week off just to see the difference and it wasn't super noticeable.AggieRuss said:
I have crossfit trained for 1 year and have eaten healthy prepped meals consistently for the last year. I'm 5'10", 47 years old and started at 215 pounds. I was definitely stronger from working out but could only lose about 7 pounds, had flab everywhere, had crazy sugar urges and always thought about food. I had a BMI of 33%. I have been on a compounded semaglutide for about 4 months. I still workout 4-5 days/week. I still eat prepped meals but I now weigh 179 pounds. My BMI is about 23%. The semaglutide is the only thing I have changed. I went to my yearly checkup 2 weeks and all of my blood tests came back perfect! No pre-diabetes or anything even close to address. My doc emailed me to say that I was in exceptional shape and to keep up the semaglutide, eating properly and working out. My goal is 170-175. Eat properly, take fiber and drink a ton of water.
I decided to try it after my wife lost ~40 pounds on Ozempic. I just wanted a kick start to losing weight and it definitely works.
but some people think and probably do take semiglutides and still eat pizza and crap, and probably still works but once you get off, those people are most likely to gain it back.
I don't think I will have any trouble maintaining once I get to my goal weight. But will take ~ 5-6 months so going slow and happy with 2 lbs per week.
It really reduces cravings and over eating. Also becoming very popular in addiction circles like AA because it does reduce cravings. Hate to say it, and my wife probably is happy with it, but does reduce seggs cravings too.
does anyone have any skepticism or concern this becomes the next "opiod" type thing? it just seems too good to be true - which often times means there's something lurking we havent thought about yet...
Many people feel this way. Many insurance companies that write pharmacist e&o or professional liability for compound pharmacies are starting to exclude semaglutide claims too.
Diabetics have been prescribed glp1 antagonists going back 20 years now. It just took some Hollywood folks to do it and for companies to make it not a needle stabbing yourself process and boom. Wildfire.
Honestly, this should lower our overall healthcare costs if it prevents CV disease. Diabetes. And other weight related ailments.
Honestly, this should lower our overall healthcare costs if it prevents CV disease. Diabetes. And other weight related ailments.
Ya'll do what you want but at least for me I wouldn't take these. There are two guys in my office that are ~60 and are taking one of these. They have both lost a bunch of weight but haven't changed any other behaviors. They both look like they lost all their muscle and while thinner look all hunched forward and terrible. Zero chest anymore.
Someone above said they couldn't lose weight. Well I said the same thing. I felt I was eating healthy and good portions. My Dr even asked me if I wanted the weight loss drug. Turns out I was just eating too much!!! I quit eating breakfast and fast till ~11-12. I eat far smaller portions and do my best not to eat any bread type carbs and zero sugar/sweets. I also exercise cardio 5-6X a week (bike, walk, run) and strength train 3-4 times a week. I'm down 20 lbs and have much more muscle/tone. I'm pretty happy with this and plan on keeping it up indefinitely.
If you are using the drugs as a tool for short term, along with diet and exercise, then I would agree with it. Otherwise you are just going to blow up again once you are off it. Long term use....Count me the hell out. I'm trying my best to get off my blood pressure and statin and reduce the amount of drugs I'm taking.
Someone above said they couldn't lose weight. Well I said the same thing. I felt I was eating healthy and good portions. My Dr even asked me if I wanted the weight loss drug. Turns out I was just eating too much!!! I quit eating breakfast and fast till ~11-12. I eat far smaller portions and do my best not to eat any bread type carbs and zero sugar/sweets. I also exercise cardio 5-6X a week (bike, walk, run) and strength train 3-4 times a week. I'm down 20 lbs and have much more muscle/tone. I'm pretty happy with this and plan on keeping it up indefinitely.
If you are using the drugs as a tool for short term, along with diet and exercise, then I would agree with it. Otherwise you are just going to blow up again once you are off it. Long term use....Count me the hell out. I'm trying my best to get off my blood pressure and statin and reduce the amount of drugs I'm taking.
Agree BCOBQ98. I plan only to take a few months and exercise and eat very well daily.
But I do see the people that don't change habits and they do lose a lot of muscle and look older. I know muscle loss is a big concern in women taking it. I don't mind losing some muscle if I can lose the 40 lbs. of fat i have in my belly.
And you have to maintain at least 150 grams of protein a day if not more. 100 minimum for women.
But I do see the people that don't change habits and they do lose a lot of muscle and look older. I know muscle loss is a big concern in women taking it. I don't mind losing some muscle if I can lose the 40 lbs. of fat i have in my belly.
And you have to maintain at least 150 grams of protein a day if not more. 100 minimum for women.
Starting Zepbound this weekend. Appreciate the advice I've read in this thread. Just ordered the vitamins Kid Doc recommended. Walk about 10,000 steps every day with the dog and work out with a trainer 2x a week (need to find religion here). Travel some for work so planning to start on Saturday. And I need to be better about hitting the gym when I travel.
I started compounded tirzepatide back in May 2024. I'm down 77lbs and have never felt stronger or had more endurance. My cholesterol is back in check.
I use Push Health for my RX. It's a super simple telehealth chat to get my RX. Push sends my RX to a local compounder and I pay about $180 per month for the shots.
My diet is now focused on protein intake. Black coffee for breakfast, protein shake lunch after my daily workout, and a protein-heavy hungry root dinner. I struggle to get in over 1500 calories per day. I limit refined sugars but do not deny myself a cheat meal out with the family or a zero calorie soda occasionally.
I workout 6 days a week focusing completely on hypertrophy strength training. The only cardio I have done throughout the whole weight loss journey is walking the dog and 5 minutes of warm-up before lifting. I have gotten considerably stronger in the gym and continue to lift heavier and heavier - even after slightly tweaking my shoulder from bench press and doing some moderate recovery physical therapy.
The only side effect I've had from the GLP1s is light headedness. I have to take a beat when I get up in the morning instead of hopping out of bed like I used to pre-GLP1s.
The biggest shock to me is how I actually look forward to going to the gym. My mindset in the beginning was that I need to work out so I don't lose too much muscle and since I'm paying for the meds I need to get my money's worth. Now my mindset is that if I don't go to the gym I just won't feel as good generally. I would work out 7 days a week but I've found that I need to rest and recover at least one day.
My advice to anyone on the fence is that GLP1s are a miracle drug but go into it with the mindset that you are making a life change. I know the habits I've formed are going to stay with me even after I stop taking it once I hit my goal weight. Also, be prepared to buy new clothes and to continually donate clothes that are too big!
I use Push Health for my RX. It's a super simple telehealth chat to get my RX. Push sends my RX to a local compounder and I pay about $180 per month for the shots.
My diet is now focused on protein intake. Black coffee for breakfast, protein shake lunch after my daily workout, and a protein-heavy hungry root dinner. I struggle to get in over 1500 calories per day. I limit refined sugars but do not deny myself a cheat meal out with the family or a zero calorie soda occasionally.
I workout 6 days a week focusing completely on hypertrophy strength training. The only cardio I have done throughout the whole weight loss journey is walking the dog and 5 minutes of warm-up before lifting. I have gotten considerably stronger in the gym and continue to lift heavier and heavier - even after slightly tweaking my shoulder from bench press and doing some moderate recovery physical therapy.
The only side effect I've had from the GLP1s is light headedness. I have to take a beat when I get up in the morning instead of hopping out of bed like I used to pre-GLP1s.
The biggest shock to me is how I actually look forward to going to the gym. My mindset in the beginning was that I need to work out so I don't lose too much muscle and since I'm paying for the meds I need to get my money's worth. Now my mindset is that if I don't go to the gym I just won't feel as good generally. I would work out 7 days a week but I've found that I need to rest and recover at least one day.
My advice to anyone on the fence is that GLP1s are a miracle drug but go into it with the mindset that you are making a life change. I know the habits I've formed are going to stay with me even after I stop taking it once I hit my goal weight. Also, be prepared to buy new clothes and to continually donate clothes that are too big!
77lbs is no joke. Great job!
I started taking Ozempic in 2020 for type 2 diabetes. My GP prescribed it as a replacement for some other shot I was taking (I have forgotten the name). If memory serves the dosage was 1 mg. It was no big deal at the time, it was just an attempt to find a drug that was most effective at helping to control my blood sugar. I think at the time I believe he might have mentioned that it might help with weight loss also, but this was before it was being subscribed purely for weight loss.
Not long after beginning Ozempic I began having serious gastro issues. It wasn't immediate and I didn't consider that my diabetes meds would be having any impact along those lines, so I did not connect the two. The symptoms were essentially like having dysentery (no fever or vomiting, but all the rest of the fun). Thankfully this was during the pandemic and I was working from home, because there is no way I could have dealt with those issues in an office environment.
Over the course of the next 3 + years I saw no fewer than 4 gastroenterologists to try and find what was going on. Every one of them was given the complete list of all of the meds I was taking and their dosages, and not one of them ever mentioned the possibility that Ozempic might be at all related to my issues (and to quote Fletch "it certainly wasn't for a lack of looking"). I was scoped multiple times, repeated blood work, any number of different tests, and no cause was ever discovered.
Did I lose weight? Absolutely. However I don't attribute that to any direct workings of Ozempic, as it never really impacted my appetite, although the negative consequences of eating did probably cause me to eat less frequently and smaller amounts to a degree. I lost about 25-30 pounds during that time, but primarily because nothing was staying in my system long enough to me processed into anything.
Late in 2023 I switched to Mounjaro because Ozempic was almost impossible to get because it had begun to be widely prescribed for weight loss which created a shortage. The dosage was whatever was considered comparable with the Ozempic dosage I had been taking. With Mounjaro I did notice the appetite reduction and it was profound.
I had never in my life experienced that sensation of being full and simply not wanting to eat any more food, no matter how much was left on my plate or how good it tasted. It was eye-opening to realize that this is what I was supposed to feel like when eating. Prior to that, my experience with feeling "full" was more akin to how you feel after Thanksgiving of Christmas dinner. THAT was "full". Experiencing this was a complete game changer in terms of understanding what was going on in my body. I had never felt that with Ozempic.
In early 2024 my sister ordered Ozempic via a compounding pharmacy (for weight loss, she is not diabetic). She had an unbelievably negative reaction to the medicine (and it was within 1 hour of taking her first dose): nausea, vomiting for 24 hours, she passed out at one point in her initial bout; it took her 3 weeks to get back to feeling normal. Her having that experience caused me to start looking into the side effects of Ozempic and Mounjaro and I discovered that the side effects were remarkably similar to what I was experiencing.
So, I stopped taking Mounjaro. Within a week my gastro issues almost completely disappeared (it was 100% within 2 weeks). It was amazing. I had planned to stop temporarily as an experiment but I stopped all together once my symptoms resolved themselves. 3 + years of dysentery symptoms was enough fun for me. I have been off it for slightly over a year now and have not had any issues at all.
I realize my experience was an outlier and may have been caused as much by the relatively high starting dosage I was given. But it was/is incredibly frustrating to have seen 4 gastros and none of them even mentioned Ozempic as even a possible contributing factor, much less a cause. And part of that is because when I started taking it, Ozempic was only a diabetes med, so the sample size (and thus the opportunity for people to have experienced negative side effects) was much smaller than now.
It's also disappointing because I can see the effect Mounjaro had on my appetite and know that it would have really helped with my weight loss, which in and of itself would help my diabetes. Honestly, I wish I could take the stuff.
And yes I know, "dear diary..." lol.
Not long after beginning Ozempic I began having serious gastro issues. It wasn't immediate and I didn't consider that my diabetes meds would be having any impact along those lines, so I did not connect the two. The symptoms were essentially like having dysentery (no fever or vomiting, but all the rest of the fun). Thankfully this was during the pandemic and I was working from home, because there is no way I could have dealt with those issues in an office environment.
Over the course of the next 3 + years I saw no fewer than 4 gastroenterologists to try and find what was going on. Every one of them was given the complete list of all of the meds I was taking and their dosages, and not one of them ever mentioned the possibility that Ozempic might be at all related to my issues (and to quote Fletch "it certainly wasn't for a lack of looking"). I was scoped multiple times, repeated blood work, any number of different tests, and no cause was ever discovered.
Did I lose weight? Absolutely. However I don't attribute that to any direct workings of Ozempic, as it never really impacted my appetite, although the negative consequences of eating did probably cause me to eat less frequently and smaller amounts to a degree. I lost about 25-30 pounds during that time, but primarily because nothing was staying in my system long enough to me processed into anything.
Late in 2023 I switched to Mounjaro because Ozempic was almost impossible to get because it had begun to be widely prescribed for weight loss which created a shortage. The dosage was whatever was considered comparable with the Ozempic dosage I had been taking. With Mounjaro I did notice the appetite reduction and it was profound.
I had never in my life experienced that sensation of being full and simply not wanting to eat any more food, no matter how much was left on my plate or how good it tasted. It was eye-opening to realize that this is what I was supposed to feel like when eating. Prior to that, my experience with feeling "full" was more akin to how you feel after Thanksgiving of Christmas dinner. THAT was "full". Experiencing this was a complete game changer in terms of understanding what was going on in my body. I had never felt that with Ozempic.
In early 2024 my sister ordered Ozempic via a compounding pharmacy (for weight loss, she is not diabetic). She had an unbelievably negative reaction to the medicine (and it was within 1 hour of taking her first dose): nausea, vomiting for 24 hours, she passed out at one point in her initial bout; it took her 3 weeks to get back to feeling normal. Her having that experience caused me to start looking into the side effects of Ozempic and Mounjaro and I discovered that the side effects were remarkably similar to what I was experiencing.
So, I stopped taking Mounjaro. Within a week my gastro issues almost completely disappeared (it was 100% within 2 weeks). It was amazing. I had planned to stop temporarily as an experiment but I stopped all together once my symptoms resolved themselves. 3 + years of dysentery symptoms was enough fun for me. I have been off it for slightly over a year now and have not had any issues at all.
I realize my experience was an outlier and may have been caused as much by the relatively high starting dosage I was given. But it was/is incredibly frustrating to have seen 4 gastros and none of them even mentioned Ozempic as even a possible contributing factor, much less a cause. And part of that is because when I started taking it, Ozempic was only a diabetes med, so the sample size (and thus the opportunity for people to have experienced negative side effects) was much smaller than now.
It's also disappointing because I can see the effect Mounjaro had on my appetite and know that it would have really helped with my weight loss, which in and of itself would help my diabetes. Honestly, I wish I could take the stuff.
And yes I know, "dear diary..." lol.
“Socialism is a philosophy of failure, the creed of ignorance, and the gospel of envy. It's inherent virtue is the equal sharing of miseries." - Winston Churchill
1 month in on Zepbound. Lost about 10 pounds on the intro dose. Bumped to the maintenance dose this week. So far so good. Very few side effects outside a little heartburn and some discomfort. Eating about 1/2 of what I was and almost never feel hungry.
So, after working from home and hurting my knee that prevented me from running I had found myself ballooned up to 240 pounds. I was just very unmotivated and frustrated that I couldn't run. And I just got really lazy.
I have lost 40 pounds before by eating right and exercising, but it was always with a "full-out, hard-core, very mentally and physically taxing" process. At 56 I was finding it harder to lose weight and actually give a damn about eating normal portions. Always ate healthy just ate more than I needed (oh and ice cream).
This year, I decided to try Hims solution and bit the bullet and spent the $1980 for 1 year's worth. Insurance didn't cover anything so this comes out to about $165/month... cheapest I could find
I've always been skeptical of "get rich quick" schemes (lose weight fast with drugs), but I was ready for anything.
And DAMN!! if this stuff isn't "magic".
I started Feb 1, 2025 at 240 pounds.
Today (2.5 months later) I'm at 208.6 with very little effort on my part.
Here's my experience with it.
1. I am not hungry all the time. I hardly even want to eat
2. It stopped my snacking after dinner when wife and I would watch TV.
3. it stopped cravings for sweets and alcohol
4. When I do eat, I am full very quickly. I can't eat more than 1 serving
4.b. When we go out to eat I no longer look for the largest amount of food for the least cost. I need to factor in "can I eat all this, or if I can't will it pack up nicely to take home for leftovers" (this definitely stopped us from going to Walk-ons and me getting the Catfish platter... no way, i would be able to eat it all at restaurant and that wouldn't work as heating up later... plus it saved me 2210 calories in one meal)
5. I'm more energetic. I walk.. Play disc golf, etc
6. I haven't had to kill myself exercising/doing cardio like I did in the past.
The weight has literally melted off and I haven't had to feel like I was giving up anything to do it.
I want to get to 195, so less than 15 pounds to go... I expect a little slow down in the weight lost rate.
Now I just have to plan for maintaining once I hit that goal and it will be much faster than the full year I paid (still concerned Hims may not be able to send me the 2nd half of the prescription in June)... but maybe I'll get a refund if I'm at my goal after 6 months (which I should be).
Anywho, I'm one of the people, in my younger life, who would have turned up my nose at people taking what I perceived as a "shortcut". But screw that. I'm not going to gatekeep getting healthy.
Yeah, everyone SHOULD be able to have self-control and eat right and exercise, but not everyone is built the same mentally and physcially.
So people reading this thread... ignore the naysayers and gatekeepers.
Oh, yeah, I did not get "Ozempic face"... that seemed to be one of the naysayers biggest arguments.
6.
I have lost 40 pounds before by eating right and exercising, but it was always with a "full-out, hard-core, very mentally and physically taxing" process. At 56 I was finding it harder to lose weight and actually give a damn about eating normal portions. Always ate healthy just ate more than I needed (oh and ice cream).
This year, I decided to try Hims solution and bit the bullet and spent the $1980 for 1 year's worth. Insurance didn't cover anything so this comes out to about $165/month... cheapest I could find
I've always been skeptical of "get rich quick" schemes (lose weight fast with drugs), but I was ready for anything.
And DAMN!! if this stuff isn't "magic".
I started Feb 1, 2025 at 240 pounds.
Today (2.5 months later) I'm at 208.6 with very little effort on my part.
Here's my experience with it.
1. I am not hungry all the time. I hardly even want to eat
2. It stopped my snacking after dinner when wife and I would watch TV.
3. it stopped cravings for sweets and alcohol
4. When I do eat, I am full very quickly. I can't eat more than 1 serving
4.b. When we go out to eat I no longer look for the largest amount of food for the least cost. I need to factor in "can I eat all this, or if I can't will it pack up nicely to take home for leftovers" (this definitely stopped us from going to Walk-ons and me getting the Catfish platter... no way, i would be able to eat it all at restaurant and that wouldn't work as heating up later... plus it saved me 2210 calories in one meal)
5. I'm more energetic. I walk.. Play disc golf, etc
6. I haven't had to kill myself exercising/doing cardio like I did in the past.
The weight has literally melted off and I haven't had to feel like I was giving up anything to do it.
I want to get to 195, so less than 15 pounds to go... I expect a little slow down in the weight lost rate.
Now I just have to plan for maintaining once I hit that goal and it will be much faster than the full year I paid (still concerned Hims may not be able to send me the 2nd half of the prescription in June)... but maybe I'll get a refund if I'm at my goal after 6 months (which I should be).
Anywho, I'm one of the people, in my younger life, who would have turned up my nose at people taking what I perceived as a "shortcut". But screw that. I'm not going to gatekeep getting healthy.
Yeah, everyone SHOULD be able to have self-control and eat right and exercise, but not everyone is built the same mentally and physcially.
So people reading this thread... ignore the naysayers and gatekeepers.
Oh, yeah, I did not get "Ozempic face"... that seemed to be one of the naysayers biggest arguments.
6.
-------------------------------------------------------
"91_Aggie is right again." -YankeeAg00
"91a: You are so classy." -abl
"and i find myself agreeing with 91 yet again..." -Gramercy Riffs
"91_Aggie is right again." -YankeeAg00
"91a: You are so classy." -abl
"and i find myself agreeing with 91 yet again..." -Gramercy Riffs
One of the main things GLP-1 meds do is delay gastric emptying. Shocking to me that a GI doc would not immediately target GLP-1 as a cause of new onset GI issues.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
KidDoc said:
One of the main things GLP-1 meds do is delay gastric emptying. Shocking to me that a GI doc would not immediately target GLP-1 as a cause of new onset GI issues.
Yeah, once I made the connection I was surprised they didn't get it honestly. And not just one, but 4 GIs.
Personally I never thought a drug I was taking for diabetes would have an impact like that.
And FWIW, I very much appreciate your rational, balancing posts on the monthly "I hate fat people" threads on Politics. It's incredibly frustrating to listen to people that have clearly never struggled with weight in their lives pontificate on how easy it is to lose weight and the obvious moral and ethical shortcomings of "fatties".
“Socialism is a philosophy of failure, the creed of ignorance, and the gospel of envy. It's inherent virtue is the equal sharing of miseries." - Winston Churchill
Yep... I was dealing with this... I upped my fiber intake and I'm pretty much back on schedule.KidDoc said:
One of the main things GLP-1 meds do is delay gastric emptying. Shocking to me that a GI doc would not immediately target GLP-1 as a cause of new onset GI issues.
But on reddit, there was one person, who said they hadn't had a bowel movement in 12 days... so, people on it definitely need to know they need to change WHAT they eat instead of just how much they eat.
-------------------------------------------------------
"91_Aggie is right again." -YankeeAg00
"91a: You are so classy." -abl
"and i find myself agreeing with 91 yet again..." -Gramercy Riffs
"91_Aggie is right again." -YankeeAg00
"91a: You are so classy." -abl
"and i find myself agreeing with 91 yet again..." -Gramercy Riffs
Got on Wegovy shortly after Thanksgiving last year after I hit 270. Scale showed 238 for me yesterday. I've been trying and failing to get this weight off for years, so for me this drug is a god send. I'm trying to delay going up in dosage as much as I can, but if I hit a consistent plateau I'll increase it. Currently on the 50ml or whatever the second tier is.
Bumping this. Big Pharma strikes again.
Compounded generic semaglutide has now halted production since name brand products are now "in good supply".
There are likely millions of people paying $150/month that are about to have to find a place to get name brand, driving their cost point up and then likely again straining supply and creating more profit for the name brands.
Compounded generic semaglutide has now halted production since name brand products are now "in good supply".
There are likely millions of people paying $150/month that are about to have to find a place to get name brand, driving their cost point up and then likely again straining supply and creating more profit for the name brands.
Growing number of patients claim Ozempic can come with irreversible vision loss
Not sure of the validity of these claims.
Not sure of the validity of these claims.
It has been reported there is an increased risk of a stroke to the optic nerve. To me that is consistent with dehydration and inadequate fluid intake which can often be a result of delayed gastric emptying.frankm01 said:
Growing number of patients claim Ozempic can come with irreversible vision loss
Not sure of the validity of these claims.
People are taking these with little guidance and no change from their regular diet of energy drinks and junk food- they just eat less. It is logical that not optimizing your suddenly limited caloric intake will result in predictable calamity.
--AI Query---
The correlation between GLP-1 receptor agonist (GLP-1 RA) use, such as semaglutide (Ozempic, Wegovy), and optic nerve stroke, specifically nonarteritic anterior ischemic optic neuropathy (NAION), has been investigated in recent studies, with mixed findings. NAION is a rare condition causing sudden, painless vision loss in one eye due to reduced blood flow to the optic nerve, with an incidence of 210 per 100,000 people annually. Below is a summary of the current evidence:
### Evidence Suggesting an Association
- **Observational Studies**: A 2024 study published in *JAMA Ophthalmology* found a potential association between semaglutide use and NAION. In a cohort of 16,827 patients at Massachusetts Eye and Ear, patients with type 2 diabetes (T2D) prescribed semaglutide had a 4.28-fold higher risk of NAION (HR 4.28, 95% CI 1.6211.29, P<0.001) compared to those on non-GLP-1 antidiabetic medications. For overweight or obese patients, the risk was even higher (HR 7.64, 95% CI 2.2126.36, P<0.001). Cumulative incidence over 36 months was 8.9% (T2D) and 6.7% (obesity) for semaglutide users versus 1.8% and 0.8% for non-GLP-1 users, respectively.[](https://pubmed.ncbi.nlm.nih.gov/38958939/)[](https://www.medpagetoday.com/ophthalmology/generalophthalmology/110941)
- **Case Reports**: A 2025 *JAMA Ophthalmology* study reported nine patients (average age ~58) using semaglutide or tirzepatide (another GLP-1 RA) who experienced vision issues, with seven developing NAION, one papillitis, and one paracentral acute middle maculopathy. Some cases showed atypical bilateral NAION, and symptoms appeared as early as one day to 16 months after starting GLP-1 RAs. Rapid blood sugar changes were hypothesized as a contributing factor, potentially causing optic nerve swelling due to osmotic shifts.[](https://www.medicalnewstoday.com/articles/review-3-potentially-blinding-eye-conditions-glp-1-drugs-ozempic-mounjaro)[](https://www.webmd.com/obesity/news/20250212/glp-1-drugs-again-linked-blindness-risk)
- **Mechanistic Plausibility**: GLP-1 receptors are present in the human optic nerve, and GLP-1 RAs may enhance sympathetic nervous system activity, potentially affecting optic nerve head perfusion. A small cup-to-disc ratio ("disc-at-risk") is a known NAION risk factor, and GLP-1 RA users with a ratio 0.3 may be at higher risk.[](https://aes.amegroups.org/article/view/8145/html)
### Evidence Against a Strong Association
- **Meta-Analysis of RCTs**: A 2024 meta-analysis of 69 randomized controlled trials (RCTs) found no significant increase in NAION risk with GLP-1 RAs (MH-OR 1.53, 95% CI 0.534.44, P=0.43), with eight NAION cases in GLP-1 RA arms versus four in comparators. The absolute risk increase was minimal (2.6/100,000 patient-years), but the analysis noted wide confidence intervals and insufficient events to rule out a small effect.[](https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.16076)
- **Large Database Study**: A retrospective analysis of 66 million U.S. patients found no increased NAION risk with GLP-1 RAs compared to non-GLP-1 medications, even in subgroups with T2D or obesity. The prevalence of NAION was low (0.07%0.24%), and results were consistent across sensitivity analyses.[](https://www.healio.com/news/endocrinology/20240802/glp1s-not-tied-to-higher-risk-for-form-of-optic-neuropathy-that-may-cause-blindness)
- **Study Limitations**: The *JAMA Ophthalmology* study was observational, single-center, and potentially affected by selection bias, as it focused on a specialized ophthalmology clinic. Confounding factors like diabetes severity, BMI, or cup-to-disc ratio differences were not fully controlled.[](https://www.healio.com/news/endocrinology/20240802/glp1s-not-tied-to-higher-risk-for-form-of-optic-neuropathy-that-may-cause-blindness)[](https://aes.amegroups.org/article/view/8145/html)
### Key Considerations
- **Causality Not Established**: Observational studies show an association, but causality remains unproven due to limitations like selection bias and lack of specific NAION diagnostic codes. Larger, multicenter RCTs or postmarket analyses are needed.[](https://pubmed.ncbi.nlm.nih.gov/38958939/)[](https://www.fiercepharma.com/pharma/novo-glp-1-ozempic-wegovy-linked-eye-problem-not-so-fast-analysts-say)
- **Risk Factors**: NAION risk is higher in patients with T2D, obesity, hypertension, or a crowded optic disc, which overlap with GLP-1 RA indications. Rapid glucose correction may also contribute to optic nerve issues.[](https://www.medicalnewstoday.com/articles/review-3-potentially-blinding-eye-conditions-glp-1-drugs-ozempic-mounjaro)[](https://aes.amegroups.org/article/view/8145/html)
- **Clinical Implications**: Patients on GLP-1 RAs should be monitored for vision changes, especially those with low cup-to-disc ratios or pre-existing eye conditions. Immediate ophthalmologic evaluation is recommended for sudden vision loss.[](https://www.webmd.com/obesity/news/20250212/glp-1-drugs-again-linked-blindness-risk)[](https://www.buffalo.edu/ubnow/stories/2025/02/glp-1-drugs-vision-jama.html)
### Conclusion
There is evidence suggesting a potential association between GLP-1 RA use (particularly semaglutide) and an increased risk of NAION, with hazard ratios indicating a 47-fold higher risk in observational data. However, RCTs and large database analyses have not confirmed a significant risk, and the rarity of NAION complicates definitive conclusions. Patients with risk factors like T2D, obesity, or a low cup-to-disc ratio may need closer monitoring. Always consult an ophthalmologist if vision changes occur while using GLP-1 RAs, but the drugs' benefits for diabetes and weight management often outweigh rare risks in most cases.[](https://pubmed.ncbi.nlm.nih.gov/38958939/)[](https://www.healio.com/news/endocrinology/20240802/glp1s-not-tied-to-higher-risk-for-form-of-optic-neuropathy-that-may-cause-blindness)
If you'd like me to generate a chart visualizing the hazard ratios or incidence rates from these studies, please confirm.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
4 month update on GLP-1. I hit One-derland today. Started at 240 on Feb 1. Hit 199.2 today. 40 pounds in 4 months with literally no effort on my part.
This stuff is amazing and can see how this could be life changing for people that are morbidly obese or have been obese their entire lives if only it could be affordable for everyone (and you didn't have a bunch of people trying to stigmatized the use of it because it is "the easy way out".
This stuff is amazing and can see how this could be life changing for people that are morbidly obese or have been obese their entire lives if only it could be affordable for everyone (and you didn't have a bunch of people trying to stigmatized the use of it because it is "the easy way out".
-------------------------------------------------------
"91_Aggie is right again." -YankeeAg00
"91a: You are so classy." -abl
"and i find myself agreeing with 91 yet again..." -Gramercy Riffs
"91_Aggie is right again." -YankeeAg00
"91a: You are so classy." -abl
"and i find myself agreeing with 91 yet again..." -Gramercy Riffs
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